Professor Dame Angela McLean, MA, PhD, FRS

Research Interests

My research interests lie in the use of mathematical models to aid our understanding of the evolution and spread of infectious agents. This encompasses modelling of the dynamics of infections and immune responses within individual hosts as well as models of the spread of infections from one host to another. 

I am also interested in the use of natural science evidence in formulating public policy and have co-developed the Oxford Martin School Restatements. Restatements list relevant scientific evidence in areas where policy making is controversial. By separating out scientific debate (what do we know?) from policy debate (what should we do?) restatements facilitate the use of natural science evidence in formulating policy.

My colleagues and I currently receive funding from the James Martin 21st Century School and I am Director of The Institute for Emergent Infections of Humans.

Contact Details

Selected Publications

Fryer, H.R., Wolinsky, S.M. and McLean, A.R., 2018. Increased T cell trafficking as adjunct therapy for HIV-1. PLoS computational biology, 14(3), p.e1006028.

Rook, G., Bäckhed, F., Levin, B.R., McFall-Ngai, M.J. and McLean, A.R., 2017. Evolution, human-microbe interactions, and life history plasticity. The Lancet, 390(10093), pp.521-530.

McLean, A.R., Adlen, E.K., Cardis, E., Elliott, A., Goodhead, D.T., Harms-Ringdahl, M., Hendry, J.H., Hoskin, P., Jeggo, P.A., Mackay, D.J. and Muirhead, C.R., 2017. A restatement of the natural science evidence base concerning the health effects of low-level ionizing radiation. Proc. R. Soc. B, 284(1862), p.20171070.

Lorenzo-Redondo, R., Fryer, H.R., Bedford, T., Kim, E.Y., Archer, J., Pond, S.L.K., Chung, Y.S., Penugonda, S., Chipman, J.G., Fletcher, C.V. and Schacker, T.W., 2016. Persistent HIV-1 replication maintains the tissue reservoir during therapy. Nature, 530(7588), p.51.

San Millan, A., Peña-Miller, R., Toll-Riera, M., Halbert, Z.V., McLean, A.R., Cooper, B.S. and MacLean, R.C., 2014. Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids. Nature communications, 5, p.5208.

 

 

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