Dr José Lourenço

Research Interests

My D.Phil and first postdoctoral research projects were in the context of the population biology and control of dengue viruses, while my current research is focused on other viruses such as HIV, FluA, and HBV. I have recently started to work in the population biology of Streptococcus bacterium species. In general, my research interests are on the biological determinants of the population dynamics and genetics of multi-strain pathogens (ex. ecological, demographic, evolutionary, etc).

I am particularly keen in the application of mechanistic, dynamical models that allow for the interpretation of the biological system in terms of the individual behaviour and short-term evolution of both the host and pathogen (Individual-based models). 

 

Selected Publications

For complete list: see Scholar page

Selected

(2019) HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model. BMC Medicine.

(2019) Reverse immunodynamics: a new method for identifying targets of protective immunity. Nature Scientific Reports.

(2018) A naturally protective epitope of limited variability as an influenza vaccine target. Nature Communications.

(2018) Genomic and epidemiological monitoring of yellow fever virus transmission potential. Science

(2018) The generation of a simian adenoviral vectored HCV vaccine. Vaccine 

(2018) Vaccination Can Drive An Increase In Frequencies Of Antibiotic Resistance Among Non-Vaccine Serotypes Of Streptococcus pneumoniae. PNAS 

(2017) Lineage structure of Streptococcus pneumoniae may be driven by immune selection on the groEL heat-shock protein. Nature Scientific reports 

(2017) Epidemiological and ecological determinants of Zika virus transmission in an urban setting. eLife

(2016) The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study. PLoS medicine 

(2016) Zika virus in the Americas: Early epidemiological and genetic findings. Science 

(2015) MANTIS: an R package that simulates multilocus models of pathogen evolution. BMC bioinformatics

(2014) The 2012 Madeira dengue outbreak: epidemiological determinants and future epidemic potential. PLoS NTDs 

(2014) Natural, Persistent Oscillations in a Spatial Multi-Strain Disease System with Application to Dengue. PLoS Comp Bio 

(2010) Viral and epidemiological determinants of the invasion dynamics of novel dengue genotypes. PLoS NTDs

 

List of site pages