Dr Irem Sepil

Research Interests

My research addresses an important but understudied aspect of reproductive ageing: declining ejaculate performance with male age. Using Drosophila melanogaster, the model organism for ageing and ejaculate research, I investigate (i) how ageing affects the male ejaculate, and variables that influence the rate of ejaculate ageing, (ii) the consequences of male reproductive ageing for sexual selection and sexual conflict. I use quantitative proteomic and cell-labelling techniques to study the age-related decline in the ejaculate; and to test the effects of lifespan-mediating interventions on ejaculate ageing. I am also interested in male reproductive strategies, sexual selection, sperm competition and life history.

  • The Drosophila seminal proteome and its role in postcopulatory sexual selection

  • Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in Drosophila.

  • Structural variation in Drosophila melanogaster spermathecal ducts and its association with sperm competition dynamics.

  • Divergent allocation of sperm and the seminal proteome along a competition gradient in Drosophila melanogaster.

  • BMP-signalling inhibition in Drosophila secondary cells remodels the seminal proteome, and self and rival ejaculate functions

  • Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster.

  • Male relatedness and familiarity are required to modulate male-induced harm to females in Drosophila.

  • Plasmodium Infections in Natural Populations of Anolis sagrei Reflect Tolerance Rather Than Susceptibility.

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