Professor Peter Holland FRS

Research Interests

I am interested in how the evolution of animal diversity can be explained through evolution of the genome. We use genome sequencing, transcriptomics, cell culture, gene expression and bioinformatics to analyse the evolution of homeobox genes, particularly in relation to gene and genome duplication. Currently, we are studying the evolution of homeobox genes and their functions in mammals, insects, molluscs and amphioxus.

Selected Publications

Paps J, Holland PWH (2018) Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty. Nature Communications

Royall AH, Maeso I, Dunwell TL, Holland PWH (2018) Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarities between paralogous mouse and human homeobox genes. EvoDevo 9: 2

Hargreaves AD, …, Zhang G, Heller RS, Holland PWH (2017) Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. PNAS 114: 7677-7682.

Maeso I*, Dunwell TL*, Wyatt CDR, Marletaz F, Veto B, Bernal JA, Quah S, Irimia M, Holland PWH (2016) Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals. BMC Biol. 14, 45

Marletaz, F, Maeso I, Faas L, Isaacs HV, Holland PWH (2015) Cdx ParaHox genes acquired distinct developmental roles after genome duplication in vertebrate evolution. BMC Biol 13, 56

Holland ND, Holland LZ, Holland PWH (2015) Scenarios for the making of vertebrates. Nature 520, 450-455

Ferguson L*, Marletaz F*, Carter J-M*, Taylor WR, Gibbs M, Breuker CJ, Holland PWH (2014) Ancient expansion of the Hox cluster in Llepidoptera generated four homeobox genes implicated in extra-embryonic tissue formation. PLoS Genetics 10: e10004698

Holland, P.W.H. (2012) Advanced Review: The evolution of homeobox genes. WIREs Developmental Biology. DOI: 10.1002/wdev.78

Holland, Peter (2011) The Animal Kingdom: a Very Short Introduction. Oxford University Press. £ 7.99

Putnam, N.H., (32 others), Holland, L.Z., Holland, P.W.H., Satoh, N. and Rokhsar, D.S. (2008) The amphioxus genome and the evolution of the chordate karyotype. Nature 453, 1064-1072

Holland, L.Z., (61 others), Satoh, N. and Holland, P.W.H. (2008) The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Research 18, 1100-1111


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