Professor Julian Parkhill

Research Interests

Julian is the Board of Management representative for the Infection Genomics Programme at the Sanger Institute. He uses high-throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host interactions.

My early work at the Institute involved the analysis of reference genomes for pathogens of fundamental importance for human health, including the causative agents of tuberculosis, plague, typhoid fever, whooping cough, leprosy, diphtheria and meningitis.

Currently, my group is using high-throughput genomic approaches to understand the evolution of bacterial pathogens on short and long timescales; how they transmit between hosts on a local and global scale, how they adapt to different hosts and how they respond to natural and human-induced selective pressures.

Our research involves population genetics, phylogenetics and phylogeography, as well as phenotypic approaches such as RNASeq, and high-throughput mutagenesis.

Publications