Dr Julien Theze

Research Interests

I am a computational evolutionary biologist with broad interests in viral evolution, genome evolution, mobile genetic element evolution, and ecology. My previous research focused on insect virus macroevolution. My current research focuses on investigating the evolutionary dynamics of human and animal pathogens, combining genetic, spatial and ecological information.

My projects involve: 

  1. investigating pathogen cross-species transmission and host shifts
  2. uncovering the spatio-temporal dynamics of pathogens
  3. identifying drivers underlying pathogen spread
  4. developing methods for pathogen discoveries in animal populations

Contact Details

Selected Publications

da Costa AC*, Thézé J*, Komninakis SCV, Sanz-Duro RL, Felinto MRL, Moura LCC, de Oliveira Barroso IM, Santos LEC, de Lemos Nunes MA, Moura AA, Lourenço J, Deng X, Delwart EL, dos Anjos Silva Guimarães MR, Pybus OG, Sabino EC, Faria NR (2017) Spread of Chikungunya virus East/Central/South African genotype in northeast Brazil. Emerging Infectious Diseases 23:1742-1744. DOI: 10.3201/eid2310.170307.

Faria NR*, Quick J*, Claro IM*, Thézé J*, de Jesus JG*, Giovanetti M*, Kraemer MUG*, Hill SC*, Black A*, da Costa AC, Franco LC, Silva SP, Wu CH, Raghwani J, Cauchemez S, du Plessis L, Verotti MP, de Oliveira WK, Carmo EH, Coelho GE, Santelli ACFS, Vinhal LC, Henriques CM, Simpson JT, Loose M, Andersen KG, Grubaugh ND, Somasekar S, Chiu CY, Muñoz-Medina JE, Gonzalez-Bonilla CR, Arias CF, Lewis-Ximenez LL, Baylis SA, Chieppe AO, Aguiar SF, Fernandes CA, Lemos PS, Nascimento BLS, Monteiro HAO, Siqueira IC, de Queiroz MG, de Souza TR, Bezerra JF, Lemos MR, Pereira GF, Loudal D, Moura LC, Dhalia R, França RF, Magalhães T, Marques ET Jr, Jaenisch T, Wallau GL, de Lima MC, Nascimento V, de Cerqueira EM, de Lima MM, Mascarenhas DL, Neto JPM, Levin AS, Tozetto- Mendoza TR, Fonseca SN, Mendes-Correa MC, Milagres FP, Segurado A, Holmes EC, Rambaut A, Bedford T, Nunes MR, Sabino EC, Alcantara LCJ, Loman NJ, Pybus OG (2017) Establishment and cryptic transmission of Zika virus in Brazil and the Americas. Nature 546:406-410. DOI: 10.1038/nature22401.

Grubaugh ND*, Ladner JT*, Kraemer MUG*, Dudas G*, Tan AL*, Gangavarapu K*, Wiley MR*, White S*, Thézé J*, Magnani DM, Prieto K, Reyes D, Bingham AM, Paul LM, Robles-Sikisaka R, Oliveira G, Pronty D, Barcellona CM, Metsky HC, Baniecki ML, Barnes KG, Chak B, Freije CA, Gladden-Young A, Gnirke A, Luo C, MacInnis B, Matranga CB, Park DJ, Qu J, Schaffner SF, Tomkins-Tinch C, West KL, Winnicki SM, Wohl S, Yozwiak NL, Quick J, Fauver JR, Khan K, Brent SE, Reiner RC Jr, Lichtenberger PN, Ricciardi MJ, Bailey VK, Watkins DI, Cone MR, Kopp EW 4th, Hogan KN, Cannons AC, Jean R, Monaghan AJ, Garry RF, Loman NJ, Faria NR, Porcelli MC, Vasquez C, Nagle ER, Cummings DAT, Stanek D, Rambaut A, Sanchez-Lockhart M, Sabeti PC, Gillis LD, Michael SF, Bedford T, Pybus OG, Isern S, Palacios G, Andersen KG (2017) Genomic epidemiology reveals multiple introductions of Zika virus into the United States. Nature 546:401-405. DOI: 10.1038/nature22400.

Leclercq S*, Thézé J*, Chebbi MA, Giraud I, Moumen B, Ernenwein L, Grève P, Gilbert C, Cordaux R (2016) Birth of a W sex chromosome by horizontal transfer of Wolbachia bacterial symbiont genome. Proceedings of the National Academy of Sciences of the USA 113:15036-15041. DOI: 10.1073/pnas.1608979113.

Spiri AM*, Thézé J*, Meli ML, Cattori V, Berger A, Steinrigl A, Pybus OG, Hofmann-Lehmann R, Willi B (2016) The genetic diversity and phenotypic associations of feline caliciviruses from cats in Switzerland. Journal of General Virology 97:3253-3266. DOI: 10.1099/jgv.0.000622.

Naccache SN*, Thézé J*, Sardi SI, Somasekar S, Greninger AL, Bandeira AC, Campos GS, Tauro LB, Faria NR, Pybus OG, Chiu CY (2016). Distinct Zika virus lineage in Salvador, Bahia, Brazil. Emerging Infectious Diseases 22:1788- 1792. DOI: 10.3201/eid2210.160663.

Faria NR, Azevedo RD, Kraemer MU, Souza R, Cunha MS, Hill SC, Thézé J, Bonsall MB, Bowden TA, Rissanen I, Rocco IM, Nogueira JS, Maeda AY, Vasami FG, Macedo FL, Suzuki A, Rodrigues SG, Cruz AC, Nunes BT, Medeiros DB, Rodrigues DS, Nunes Queiroz AL, Silva EV, Henriques DF, Travassos da Rosa ES, de Oliveira CS, Martins LC, Vasconcelos HB, Casseb LM, Simith DB, Messina JP, Abade L, Lourenço J, Alcantara LC, Lima MM, Giovanetti M, Hay SI, de Oliveira RS, Lemos PD, Oliveira LF, de Lima CP, da Silva SP, Vasconcelos JM, Franco L, Cardoso JF, Vianez- Junior JL, Mir D, Bello G, Delatorre E, Khan K, Creatore M, Coelho GE, de Oliveira WK, Tesh R, Pybus OG, Nunes MR, Vasconcelos PF (2016) Zika virus in the Americas: early epidemiological and genetic findings. Science 352:345-349. DOI: 10.1126/science.aaf5036.

Pybus OG and Thézé J (2016) Hepacivirus cross-species transmission and the origins of the hepatitis C virus. Current Opinion in Virology 16:1-7. DOI: 10.1016/j.coviro.2015.10.002. 

List of site pages