Holland Lab

holland lab
Holland Lab

About the Group

A major goal of our research is to understand the genetic basis of animal diversity, and a second is to use comparative genome data to illuminate human biology. These areas of science are particularly exciting as new experimental and analytical tools can now be applied to long-standing puzzles and problems.

A group of regulatory genes known as homeobox genes are a particular focus of our research. Currently, we are addressing the role of unusual homeobox genes in early development of the embryo and in the biology of the gut and pancreas, and using comparisons between species to understand how new genes arise and gain new roles.

For more information visit: https://zoo-pholland.zoo.ox.ac.uk 

Members

Prof Peter Holland

Amy Royall
Serena Dai

Recent Publications

Hargreaves AD et al. (2017) Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster.  PNAS 114: 7677-7682. doi:10.1073/pnas.1702930114

Dunwell TL, Paps J, Holland PWH (2017) Novel and divergent genes in the evolution of placental mammals. Proc Roy Soc B. 20171357. doi:10.1098/rspb.2017.1357

Dunwell, TL, Holland PWH (2017) A sister of NANOG regulates genes expressed in pre-implantation human development. Open Biology 7:  170027. doi:10.1098/rsob.170027

Maeso I, Dunwell TL, Wyatt CDR, Marlétaz F, Vető B, Bernal JA, Quah S, Irimia M, Holland PWH (2016) Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals. BMC Biology 14: 45. doi:10.1186/s12915-016-0267-0

Ferguson L, Marlétaz F, Carter JM, Taylor WR, Gibbs M, Breuker CJ, Holland PWH (2014) Ancient expansion of the Hox cluster in Lepidoptera generated four homeobox genes implicated in extra-embryonic tissue formation. PLoS Genetics 10: e1004698. doi:10.1371/journal.pgen.1004698

List of site pages