Holland Lab

holland lab
Holland Lab

About the Group

A major goal of our research is to understand the genetic basis of animal diversity, and a second is to use comparative genome data to illuminate human biology. These areas of science are particularly exciting as new experimental and analytical tools can now be applied to long-standing puzzles and problems.

A group of regulatory genes known as homeobox genes are a particular focus of our research. Currently, we are addressing the role of unusual homeobox genes in early development of the embryo and in the biology of the gut and pancreas, and using comparisons between species to understand how new genes arise and gain new roles.

For more information visit: https://zoo-pholland.zoo.ox.ac.uk 

Recent Publications

Dai, Y. and Holland, P. W. H. , “The interaction of natural selection and GC skew may drive the fast evolution of a sand rat homeobox gene.”, Mol Biol Evol, 2019.

Royall, A. H. , Frankenberg, S. , Pask, A. J. , and Holland, P. W. H. , “Of eyes and embryos: subfunctionalization of the CRX homeobox gene in mammalian evolution.”, Proc Biol Sci, vol. 286, no. 1907, p. 20190830, 2019.

Marlétaz, F. , Firbas, P. N. , Maeso, I. , Tena, J. J. , Bogdanovic, O. , Perry, M. , Wyatt, C. D. R. , de la Calle-Mustienes, E. , Bertrand, S. , Burguera, D. , Acemel, R. D. , van Heeringen, S. J. , Naranjo, S. , Herrera-Ubeda, C. , Skvortsova, K. , Jimenez-Gancedo, S. , Aldea, D. , Marquez, Y. , Buono, L. , Kozmikova, I. , Permanyer, J. , Louis, A. , Albuixech-Crespo, B. , Le Petillon, Y. , Leon, A. , Subirana, L. , Balwierz, P. J. , Duckett, P. Edward, Farahani, E. , Aury, J. - M. , Mangenot, S. , Wincker, P. , Albalat, R. , Benito-Gutiérrez, E. , Cañestro, C. , Castro, F. , D'Aniello, S. , Ferrier, D. E. K. , Huang, S. , Laudet, V. , Marais, G. A. B. , Pontarotti, P. , Schubert, M. , Seitz, H. , Somorjai, I. , Takahashi, T. , Mirabeau, O. , Xu, A. , Yu, J. - K. , Carninci, P. , Martinez-Morales, J. Ramon, Crollius, H. Roest, Kozmik, Z. , Weirauch, M. T. , Garcia-Fernàndez, J. , Lister, R. , Lenhard, B. , Holland, P. W. H. , Escrivá, H. , Gómez-Skarmeta, J. Luis, and Irimia, M. , “Amphioxus functional genomics and the origins of vertebrate gene regulation.”, Nature, vol. 564, no. 7734, pp. 64-70, 2018.

Royall, A. H. , Maeso, I. , Dunwell, T. L. , and Holland, P. W. H. , “Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes.”, Evodevo, vol. 9, p. 2, 2018.

Paps, J. and Holland, P. W. H. , “Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty.”, Nat Commun, vol. 9, no. 1, p. 1730, 2018.

Holland, P. W. H. , “The dawn of amphioxus molecular biology - a personal perspective”, International Journal of Developmental Biology, vol. 61, 2017.

Hargreaves, A. D. , Zhou, L. , Christensen, J. , Marlétaz, F. , Liu, S. , Li, F. , Jansen, P. Gildsig, Spiga, E. , Hansen, M. Thye, Pedersen, S. Vendelbo H. , Biswas, S. , Serikawa, K. , Fox, B. A. , Taylor, W. R. , Mulley, J. Frederick, Zhang, G. , R Heller, S. , and Holland, P. W. H. , “Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster.”, Proc Natl Acad Sci U S A, vol. 114, no. 29, pp. 7677-7682, 2017.

Holland, P. W. H. , Marlétaz, F. , Maeso, I. , Dunwell, T. L. , and Paps, J. , “New genes from old: asymmetric divergence of gene duplicates and the evolution of development.”, Philos Trans R Soc Lond B Biol Sci, vol. 372, no. 1713, 2017.

Dunwell, T. L. , Paps, J. , and Holland, P. W. H. , “Novel and divergent genes in the evolution of placental mammals.”, Proc Biol Sci, vol. 284, no. 1864, 2017.

Dunwell, T. L. and Holland, P. W. H. , “A sister of NANOG regulates genes expressed in pre-implantation human development”, Open Biology, 2017.