Angela McLean

Research Interests

My research interests lie in the use of mathematical models to aid our understanding of the evolution and spread of infectious agents. This encompasses modelling of the dynamics of infections and immune responses within individual hosts as well as models of the spread of infections from one host to another. My group's current research interests focus on:

• HIV
• HCV
• Influena
• Scrapie

My colleagues and I currently receive funding from the James Martin 21st Century School and I am Director of The Institute for Emergent Infections of Humans.

Other Interests

I am a Fellow of All Souls College. I am currently a member of the Science Advisory Council of Defra where I chair a sub-group considering Defra’s use of scientific risk appraisal. I also sit on the National Expert Panel for New and Emerging Infections at the Department of Health and the European Academies Science Advisory Council working group on Migration and Infectious Disease.

Contacts

Selected Publications

• Arinaminpathy N., McLean A.R. (2008) Antiviral treatment for the control of pandemic influenza: some logistical constraints. J. R. Soc Interface 5: 545-553
• Fryer, H.R., Baylis, M., Sivam, K., McLean, A.R. (2007) Quantifying the risk from ovine BSE and the impact of control strategies Proc Biol Sci. 274: 1497-503
• R. Asquith A.R. McLean. (2007) In vivo CD8+ T Cell Killing of Immunodeficiency Virus-Infected Cells in Humans and Macaques PNAS 104: 6365-70
• R. Asquith, C.T.T. Edwards, M. Lipsitch, A. R. McLean (2006) Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo (2007) PLOS Biology 4: e90
• A. Scherer J. Frater A. Oxenius J. Agudelo, D. A. Price, H. F. Günthard, M. Barnardo, L. Perrin, B. Hirschel, R. E. Phillips, A. R. McLean (2004) Quantifiable CTL responses and HLA-related risk of progression to AIDS PNAS 10112266-12270