Angela Brueggemann

Research Interests

My main research focus is Streptococcus pneumoniae (the ‘pneumococcus’), a bacterium that is a major cause of diseases such as otitis media, pneumonia and meningitis worldwide. My research involves using molecular genotyping techniques to understand pneumococcal population biology and evolution, especially related to the pneumococcal vaccine and vaccine escape. This work has important implications for the long-term effectiveness of the current pneumococcal vaccine and for the design of future vaccines. Other research projects relate to bacterial pathogenesis and paediatric respiratory infections

Other Interests

I am an advisor to Wyeth Vaccines and GlaxoSmithKline Biologicals; a member of the Pneumococcal Molecular Epidemiology Network International Committee; and a member of the European Society for Paediatric Infectious Diseases, Society for General Microbiology and the American Society for Microbiology

Contacts

Selected Publications

• Brueggemann, AB, Pai, R, Crook, DW and Beall, B. Vaccine escape recombinants emerge after pneumococcal vaccination in the United States. PLoS Pathog, 2007;3: e168
• Obando, I, Arroyo, LA, Sanchez-Tatay, D, Moreno, D, Hausdorff, WP, and Brueggemann, AB. Molecular typing of pneumococci causing parapneumonic empyema in Spanish children using multilocus sequence typing directly on pleural fluid samples. Pediatr Infect Dis J 2006;25(10):962-963
• Rose, PW, Harnden, A, Brueggemann, AB, Perera, R, Sheikh, A, Crook, D and Mant, D. Chloramphenicol for the treatment of acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet 2005;366:37-43
• Brueggemann, AB, Peto, TEA, Crook, DW, Butler, JC, Kristinsson, KG, and Spratt, BG. Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children. J Infect Dis 2004;190:1203-11
• Brueggemann, AB, Griffiths, DT, Meats, E, Peto, T, Crook, DW and Spratt, BG. Clonal relationships between invasive and carriage Streptococcus pneumoniae, and serotype- and clone-specific differences in invasive disease potential. J Infect Dis 2003;187:1424-32