Oliver Pybus

Professor of Evolution & Infectious Disease

Professorial Fellow, New College

 

Research Interests

My research aims to explain the evolutionary dynamics of pathogens, particularly viral infections of humans, including HIV/AIDS, the Hepatitis C Virus, and Influenza. I hope to understand how evolutionary and ecological processes - which occur on the same timescale for many pathogens - combine and interact in natural populations.

 

Contacts

Email: oliver.pybus@zoo.ox.ac.uk
 

Websites

 

Selected Publications

  • Pybus OG*, Suchard M*, Lemey P*, Bernardin F, Rambaut A, Crawford FW, Gray RR, Arinaminpathy N, Stramer S, Busch MP, Delwart E (2012) Unifying the spatial epidemiology and molecular evolution of emerging epidemics. Proceedings of the National Academy of Sciences USA 109:15066-71

  • Farci P et al. (2012) Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis. Proceedings of the National Academy of Sciences USA 109:14562–7

  • Vijaykrishna D*, Smith GJ*, Pybus OG*, Zhu H, Bhatt S et al.  (2011) Long-term evolution and transmission dynamics of swine influenza A virus. Nature 473:519-22

  • Katzourakis A, Gifford RJ, Tristem M, Gilbert MTP, Pybus OG (2009) Macroevolution of complex retroviruses. Science 325:1512

  • Fraser C et al. (2009) Pandemic potential of a novel strain of influenza A (H1N1): early findings. Science 324:1557-61

  • Smith GJ et al. (2009) Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122-5

  • Pybus OG*, Barnes E*, Taggart R, Lemey P, Rasachak B, Syhavong B, et al. (2009) The genetic history of the hepatitis C virus in East Asia. Journal of Virology 83:1071-82

  • Kawashima Y et al. (2009) Adaptation of HIV-1 to human leukocyte antigen class I. Nature 458:641-45

  • Pybus OG & Rambaut A (2009) Evolutionary analysis of the dynamics of viral infectious disease. Nature Reviews Genetics 10:540-50

  • Penman BS, Pybus OG, Weatherall DJ, Gupta S (2009) Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle cell gene in uncommon in the Mediterranean. Proceedings of the National Academy of Sciences USA 106:21242-6

  • Rambaut A, Pybus OG, Nelson MI, Viboud C, Taubenberger JK et al. (2008) The genomic and epidemiological dynamics of human influenza A virus. Nature 453:615-9