Pat Nuttall

Emeritus Professor

Fellow of Wolfson College

 

Research Interests

Blood-feeding arthropods such as mosquitoes and ticks act as vectors, transmitting numerous viruses (arthropod-borne viruses = arboviruses), bacteria, protozoa and other pathogens to animals, including humans.  My interest is in the role of vector saliva in pathogen transmission.  I am trying to unravel the complexity of tick saliva, which contains 100s of molecules that help the tick to feed, including anticoagulants and immunomodulators.  The remarkable activities of these molecules are exploited by vector-borne pathogens, promoting their transmission.  We also can exploit these molecules to develop vaccines and new therapeutic drugs.    

 

Contacts

Email: pat.nuttall@zoo.ox.ac.uk
 

Websites

 

Selected Publications

  • Hajnická, V., Kúdelová, M., Štibrániová, I., Slovák, M., Bartíková, P., Halásová, Z., Pančík, P., Belvončíková, P., Vrbová, M., Holíková, V., Hails, R.S. and Nuttall, P.A.  Tick-borne transmission of murine gammaherpesvirus 68.  Frontiers in Cellular and Infection Microbiology 7: 458.

  • Layzell, S.J., Bailey, D., Peacey, M., and Nuttall, P.A. (2017).  Prevalence of Borrelia burgdorferi and Borrelia miyamotoi in questing Ixodes ricinus ticks from four sites in the UK.  Tick and Tick-borne Diseases in press.

  • Iyer, J.K., Koh, C.Y., Kazimirova, M., Roller, L., Jobichen, C., Swaminathan, K., Mizuguchi, J., Iwanaga, S., Nuttall, P.A., Chan, M.Y. and Kini, R.M. (2017).  Avathrin: A a novel thrombin inhibitor derived from a multi-copy precursor in the salivary glands of the ixodid tick, Amblyomma variegatumFASEB Journal 31: 2981-2995.

  • Kazimírová, M., Thangamani, S., Bartíková, P., Hermance, M., Holíková, V., Štibrániová, I., Nuttall, P. (2017).  Tick-borne viruses and biological processes at the tick-host-virus interface.  Frontiers in Cellular and Infection Microbiology 7: 339.

  • Gargili, A., Estrada-Peña, A., Spengler, J.R., Lukashev, A., Nuttall, P., and Bente, D.A. (2017).  The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: a review of published field and laboratory studies.  Antiviral Research 144: 93-119.

  • Valdés, J.J., Cabezas-Cruz, A., Sima, R., Butterill, P.T., Ruzek, P.T., and Nuttall, P.A. (2016).  Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection.  Scientific Reports 6:32372e

  • Daniel, M., Malý, M., Danielová, V., Kriz, B. and Nuttall, P. (2015).  Abiotic predictors and annual seasonal dynamics of Ixodes ricinus, the major disease vector of Central Europe.  Parasites and Vectors 8:478.