Jessica Hedge

Postdoctoral Research Assistant

 

Research Interests

My research focuses on the molecular evolution and population dynamics of microbial pathogens. Specifically, I apply population genetics approaches to microbial whole genome sequence data to understand infectious disease evolution, both within individuals and across populations. I am currently investigating the genetic determinants of antimicrobial resistance through analysis of whole genome sequence data derived from both clinical and experimentally evolved strains of bacteria.

 

Contacts

Email: jessica.hedge@zoo.ox.ac.uk
 

Websites

 

Selected Publications

  • Hedge, J., Lamagni, T., Moore, G., Walker, J., Crook, D., & Chand, M. (2017). Mycobacterium chimaera Isolates from Heater–Cooler Units, United Kingdom. Emerging Infectious Diseases, 23(7), 1227. DOI: 10.3201/eid2307.170442

  • Chand, M., Lamagni, T., Kranzer, K., Hedge, J., Moore, G., Parks, S., et al., (2016) Insidious risk of severe Mycobacterium chimaera infection in cardiac surgery patients. Clinical Infectious Diseases, p.ciw754. DOI: 10.1093/cid/ciw754

  • Hedge, J. and Wilson, D. J. (2016) Practical approaches for detecting selection in microbial genomes. PLOS Computational Biology 12(2), e1004739 DOI: 10.1371/journal.pcbi.1004739
  • Walker, T. M., Kohl, T. A., Omar, S. V., Hedge, J., Elias, C. D. O., Bradley, P., Iqbal, Z., Feuerriegel, S., Niehaus, K., Wilson, D. J., Clifton, D. A., Kapatai, G., Ip, C. L. C., Bowden, R., Drobniewski, F., Allix-Béguec, C., Gaudin, C., Parkhill, J., Diel, R., Supply, P., Crook, D. W., Smith, E. G., Walker, A. S., Ismail, N., Niemann, S., Peto, T. E. A. and the MMM Informatics Group (2015). Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: A retrospective cohort study. The Lancet Infectious Diseases 15(10), 1193-1202 DOI: 10.1016/s1473-3099(15)00062-6

  • Hedge, J. and Wilson, D. J. (2014) Bacterial phylogenetics is robust to recombination but demographic inference is not. mBio 5(6):e02158-14 DOI: 10.1128/mbio.02158-14(15)00062-6
  • Wong, T. H. N., Dearlove, B. L., Hedge, J., Giess, A. P., Piazza, P., Trebes, A., Paul, J., Smit, E., Smith, E. G., Sutton, J., Wilcox, M. H., Dingle, K. E., Peto, T. E. A., Crook, D. W., Wilson, D. J. & Wyllie, D. H. (2013) Whole genome sequencing and de novo assembly identifies Sydney-like variant noroviruses and recombinants during the Winter 2012/2013 outbreak in England. Virology Journal 10(1), 1 DOI: 10.1186/1743-422x-10-335

  • Hedge, J., Lycett, S. J. and Rambaut, A. (2013) Real-time characterization of the molecular epidemiology of an influenza pandemic. Biology Letters 9(5) DOI: 10.1098/rsbl.2013.0331(15)00062-6
  • Baillie, G., Galiano, M., Agapow, P-M., Myers, R., Chiam, R., Gall, A., Palser, A., Watson, S., Hedge, J., Underwood, A., Platt S., Mclean, E., Pebody, R., Rambaut, A., Green, J., Daniels, R., Pybus, O., Kellam, P. & Zambon, M. (2012) Evolutionary dynamics of local pandemic H1N1/09 influenza lineages revealed by whole genome analysis. Journal of Virology 86(1), 11-18 DOI: 10.1128/jvi.05347-11

  • Hayman, D.T., Johnson, N., Horton, D.L., Hedge, J., Wakeley, P.R., Banyard, A.C., Zhang, S., Alhassan, A. & Fooks, A.R. (2011) Evolutionary history of rabies in Ghana. PLOS Neglected Tropical Diseases. 5, e1001. DOI: 10.1371/journal.pntd.0001001

  • Meehan, C.J., Hedge, J., Robertson, D.L., McCormack, G.P. & Travers, S.A. (2010) Emergence, dominance, and possible decline of CXCR4 infection. Journal of Medical Virology 82, 2004-2012. DOI: 10.1002/jmv.21922