Current Member - Dr. Hooman K. Moghadam

Dr. Hooman K. Moghadam

Details

Name: Dr. Hooman K. Moghadam
Position: Postdoctoral Researcher
Email: hooman.khaleghtmoghadam@zoo.ox.ac.uk

Autobiography

I received my M.Sc. from the Center for Genetic Improvement of Livestock, University of Guelph, Canada, where I estimated genetic parameters for various cardiovascular defects in different strains of broiler chicken (1998-2000). The focus of my doctoral work, at the Department of Integrative Biology, University of Guelph, aimed at the characterization and genomic localization of different early developmentally important candidate genes within the genomes of two tetraploid derivative species, Rainbow trout and Atlantic salmon (2000-2004). As a result of this project, I developed great interest in understanding the genetic basis of phenotypic variation both within and between species. As a postdoctoral researcher, I have worked at the University of Guelph, Hospital for Sick Children in Toronto, Cornell University and more recently at the EGI, where I have continued my interest in investigating the underlying genetic architecture of complex traits in vertebrate species as diverse as fish, dogs and birds.

Research Activities

In collaboration with Dr. Judith Mank, my current research aims to understand the role of sex-specific gene regulation and sex-specific selection in the evolution of sexual dimorphism in birds. Our understanding of how sex specific traits across many different animal species develop and evolve is very limited. However, considering that all sexually dimorphic traits are essentially the products of differences in overall gene expression patterns between males and females, we aim to investigate the genetic changes in gene expression profiles between different genders using massively parallel sequencing of RNA (RNA-Seq). This would help us to have a better understanding of the genetic network that governs the development of sex specific traits within each sex.

Selected Recent Papers

Paibomesai, M. I., Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2010) Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling. BMC RESEARCH NOTES 3: 215

Wringe, B. W., Devlin, R. H., Ferguson, M. M., Moghadam, H. K., Sakhrani, D., and Danzmann, R. G. (2010) Growth-related quantitative trait locus regions in Rainbow trout (Oncorhynchus mykiss). BMC GENETICS 11: 63

Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2009) Comparative genomics and evolution of the conserved noncoding elements (CNE) in Rainbow trout. BMC GENOMICS 10: 278

Tuziak, S., Moghadam, H. K., and Danzmann, R. G. (2009) Genetic mapping of the ornithine decarboxylase (ODC) gene complex in Rainbow trout (Oncorhynchus mykiss). CYTOGENETIC AND GENOME RESEARCH 125: 279-85

Danzmann, R. G., Davidson, E. A., Ferguson, M. M., Gharbi, K., Koop, B. F., Lien, S., Lubieniecki, K., Moghadam, H. K., Park, J., Phillips, R. B., and Davidson, W. S. (2008) Distribution of ancestral proto-Actinopterygian chromosome arms within the genomes of 4R-derivative Salmonid fishes (Rainbow trout and Atlantic salmon). BMC GENOMICS 9: 557

Haidle, L., Janssen, J. E., Gharbi, K., Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2008) Determination of sex-specific quantitative trait loci (QTL) for early maturation in Rainbow trout (Oncorhynchus mykiss). MARINE BIOTECHNOLOGY 10: 579-592

Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2007) Linkage variation at the SEX determining locus within Fraser strain Arctic charr (Salvelinus alpinus). JOURNAL OF FISH BIOLOGY 71: 294-301

Moghadam, H. K., Ferguson, M. M., Rexroad III, C. E., Coulibaly, I., and Danzmann, R. G. (2007) Genomic organization of the igf1, igf2, myf5, myf6 and grf/pacap across Salmoninae subfamilies. ANIMAL GENETICS 38: 527-532

Moghadam, H. K., Poissant, J., Fotherby, H., Haidle, L., Ferguson, M. M., and Danzmann, R. G. (2007) Quantitative trait loci for body weight, condition factor and age at sexual maturation in Arctic charr (Salvelinus alpinus): Comparative analysis with Rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar). MOLECULAR GENETICS AND GENOMICS 277: 647-661

Gharbi, K., Murray, B. W., Moghadam, H. K., Ferguson, M. M., Wright, P. A., and Danzmann, R. G. (2007) Genome organization of glutamine synthetase genes in Rainbow trout (Oncorhynchus mykiss). CYTOGENETIC AND GENOME RESEARCH 116: 113-115

Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2005) Evidence for Hox gene duplication in Rainbow trout (Oncorhynchus mykiss): A tetraploid model species. JOURNAL OF MOLECULAR EVOLUTION 61: 804-818

Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2005) Evolution of Hox clusters in Salmonidae: A comparative analysis between Atlantic salmon (Salmo salar) and Rainbow trout (Oncorhynchus mykiss). JOURNAL OF MOLECULAR EVOLUTION 61: 636-49

Moghadam, H. K., McMillan, I., Chambers, J. R., Julian, R. J., and Tranchant, C. C. (2005) Heritability of sudden death syndrome and its associated correlations to ascites and body-weight. BRITISH POULTRY SCIENCE 46: 54-57

Martyniuk, C. J., Perry, G. M. L., Moghadam, H. K., Ferguson, M. M., and Danzmann, R. G. (2003) The genetic architecture of correlations among growth-related traits and male age at maturation in Rainbow trout (Oncorhynchus mykiss). JOURNAL OF FISH BIOLOGY 63: 1-19

Wilson, A. J., McDonald, G., Moghadam, H. K., Herbinger, C. M., and Ferguson, M. M. (2003) Marker-assisted estimation of quantitative genetic parameters in Rainbow trout, Oncorhynchus mykiss. GENETICAL RESEARCH 81: 145-156

Moghadam, H. K., McMillan, I., Chambers, J. R., and Julian R. J. (2001) Estimation of genetic parameters for ascites syndrome in broiler chickens. POULTRY SCIENCE 80: 844-848